Downstream Processing

Your Professional Downstream Processing Supplier

Hangzhou Guidling Technology CO.,LTD is an innovative manufacturer focusing on providing solutions (clarification, separation and concentration, etc.) in the downstream field of biopharmaceutical. Guidling Technology has successfully developed centrifugal filter devices, ultrafiltration & microfiltration cassettes and TFF device and system, depth filter modules, virus clearance filter, etc.

Why Choose Us

ISO-Certified Quality Management

We are certified under ISO 9001:2015 / GB/T 19001-2016 by internationally recognized bodies (IAF/IAS), ensuring strict process control and consistently reliable product quality throughout manufacturing.

Scalable Filtration Solutions

We provide integrated clarification, filtration, and concentration systems designed to support seamless scale-up from laboratory to full-scale industrial production.

Proven Biopharma Applications

Our filtration technologies are widely used in antibody, vaccine, and biologics manufacturing, enabling stable and efficient clarification, separation, and virus removal processes.

Parameter

Connector	Luer or quick chuck joint
Animal-derived	All filters are made of synthetic materials and are not derived from animals
Integrity test	Pass the aerosol test
Operating pressure	Inlet pressure≤3bar
Operating temperature	≤37°C
Alkali resistance	At 25°C, the maximum resistance to 0.5N sodium hydroxide is 45min
PH	2-13

Benefits of Downstream Processing

High mass capacity for improved process economics

High flux for faster processing

Consistent batch-to-batch performance

Robust virus retention: ≥ 4 log removal of parvovirus

Steps in downstream processing

All downstream purification steps have the goal to recover purified substances to be used in biochemical products.

Harvest and filtration

This serves the separation from bulk debris with the intent to optimize yield and quality.

Primary capture

Aims to minimize impurities and by-products after all cell debris has been removed.

Buffer exchange and concentration

Molecules are separated using ultrafiltration based on membrane pore size or molecular weight cutoff, while diafiltration services the exchange of products from an existing buffer to a new buffer or a final formulation buffer.

Purification

Residual impurities are removed, while at the same time as much product as possible is retained, with methods like polishing chromatography and virus inactivation.

Certificate

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Delivery Information

Air Freight

Suitable for membrane modules, filters, and urgent orders requiring fast delivery.

Sea Freight

Ideal for commercial-scale TFF systems and large production equipment shipments.

Express Delivery

Small consumables and sample orders can be shipped via DHL, FedEx, UPS, or TNT.

FAQ

Q: What is the difference between upstream and downstream processing?

A: Upstream processing refers to the initial phase of production where biological materials are cultivated and the desired product is synthesized. Downstream processing is the subsequent phase where this product is recovered, isolated, and purified from a complex mixture into a final, commercially usable form.

Q: What industries use downstream processing?

A: Biopharmaceutical downstream processing is applicable in the manufacturing process of biopharmaceuticals, such as mAb (monoclonal antibodies), various vaccines, recombinant antibodies or enzymes.

Q: What are the principles of downstream processing?

A: Downstream processing refers to the recovery, purification, and packaging of biosynthetic products (such as pharmaceuticals, enzymes, or food additives) following upstream production like fermentation.

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