Pilot / Clinical Mfg.

Your Professional Pilot / Clinical Mfg Supplier

Hangzhou Guidling Technology CO.,LTD is an innovative manufacturer focusing on providing solutions (clarification, separation and concentration, etc.) in the downstream field of biopharmaceutical. Guidling Technology has successfully developed centrifugal filter devices, ultrafiltration & microfiltration cassettes and TFF device and system, depth filter modules, virus clearance filter, etc.

Why Choose Us

ISO-Certified Quality Management

We are certified under ISO 9001:2015 / GB/T 19001-2016 by internationally recognized bodies (IAF/IAS), ensuring strict process control and consistently reliable product quality throughout manufacturing.

Scalable Filtration Solutions

We provide integrated clarification, filtration, and concentration systems designed to support seamless scale-up from laboratory to full-scale industrial production.

Proven Biopharma Applications

Our filtration technologies are widely used in antibody, vaccine, and biologics manufacturing, enabling stable and efficient clarification, separation, and virus removal processes.

Parameter

Reservoir O-ring	EP Rubber
Magnetic Stir Bar	PTFE coated
Gauge Wetted Parts	316L stainless steel
Gauge Mounting Block	Polypropylene
Luer Fittings	Polypropylene and stainless steel
Tubing	C-flex﹡
Four-way Valves	Polycarbonate body, polyethylene core
Drip Tray	Urethane

Benefits of Pilot & Clinical Mfg

TFF is Easy To Set Up And Use

Simply connect the TFF device to a pump and pressure gauge(s) with tubing and a few fittings, add your sample to the reservoir and you’re ready to go.

TFF is Fast And Efficient

It is easier to set up and much faster than dialysis. You can achieve higher concentrations in less time than with centrifugal devices or stirred cells.

Perform Two Steps With One System

You can concentrate and diafilter a sample on the same system, saving time and avoiding product loss.

TFF Can Be Scaled-up Or Scaled-down

Materials of construction and cassette path length allow conditions established during pilot-scale trials to be applied to process- scale applications. TFF devices are available that can process sample volumes as small as 10 mL or as large as thousands of liters.

TFF is Economical

TFF devices and cassettes can be cleaned and reused, or disposed of after single use.A simple integrity test can be performed to confirm that membrane and seals are intact.

Pilot / Clinical Mfg TFF System Configuration

Product tank or reservoir, often with weighing or level control.

Recirculation loop with the main tangential flow pump.

Membrane holder or housing for cassette, hollow fiber or other module formats.

Pressure, flow and temperature instrumentation.

Permeate and diafiltration lines.

Control software for modes, alarms, recipes, reports and data export.

Lab Scale Tangential Flow Filtration System best

Application of Pilot & Clinical Mfg

Biotechnology and Pharmaceuticals

Concentration of therapeutic proteins, antibody purification, virus filtration

Food and Beverage

Clarification of juices and broths, concentration of enzymes and flavor compounds

Environmental and Water Testing

Microbial concentration, particulate separation from large water samples

Industrial and Materials Processing

Colloid separation, catalyst recovery, particle fractionation

Certificate

productcate-1-1

Shipping and Payment Information

Shipping	We offer various shipping methods, including sea freight, air freight, and express delivery, depending on the order size and destination.
Terms Of Payment	We usually accept T/T, L/C, Paypal, Credit card, etc. If you prefer other payments terms, please feel free to discuss with us.

FAQ

Q: What is included in a Pilot / Clinical Mfg TFF system?

A: A typical Pilot / Clinical Manufacturing TFF system includes a product tank or reservoir with level or weighing control, a recirculation loop driven by a tangential flow pump, and a membrane holder designed for cassette or hollow fiber modules. The system also integrates instrumentation for pressure, flow, and temperature monitoring to ensure stable and controlled operation.

Q: How does the recirculation loop work in a TFF system?

A: The recirculation loop continuously circulates the process fluid through the membrane module using a main pump. This tangential flow helps minimize membrane fouling while maintaining consistent crossflow conditions, allowing efficient separation and stable product recovery during pilot and clinical manufacturing processes.

Q: What process controls are available in Pilot / Clinical Mfg systems?

A: These systems typically include sensors and control strategies for pressure, flow rate, and temperature. Advanced configurations may also support automated control of transmembrane pressure (TMP), process modes, alarms, recipes, and data logging for compliance, ensuring reproducibility and process consistency.

(0/10)