Commercial Mfg.

Your Professional Commercial Mfg Supplier

 

Hangzhou Guidling Technology CO.,LTD is an innovative manufacturer focusing on providing solutions (clarification, separation and concentration, etc.) in the downstream field of biopharmaceutical. Guidling Technology has successfully developed centrifugal filter devices, ultrafiltration & microfiltration cassettes and TFF device and system, depth filter modules, virus clearance filter, etc.

 

 
 
Why Choose Us
ISO-Certified Quality Management
We are certified under ISO 9001:2015 / GB/T 19001-2016 by internationally recognized bodies (IAF/IAS), ensuring strict process control and consistently reliable product quality throughout manufacturing.
Scalable Filtration Solutions
We provide integrated clarification, filtration, and concentration systems designed to support seamless scale-up from laboratory to full-scale industrial production.
Proven Biopharma Applications
Our filtration technologies are widely used in antibody, vaccine, and biologics manufacturing, enabling stable and efficient clarification, separation, and virus removal processes.

 

Parameter

Maximum Inlet Pressure

≤4.2bar(60.9 psi)

Forward Transmembrane Pressure

5.5 bar (80 psi) at 4-45 °C,220 hours continuous(3 hours continuous,0.1m2 format only) 2.5 bar (40 psi) at 4-50 °C, 50 hours continuous

Reverse Transmembrane Pressure

30 psi (2.1 bar) at 25 °C, 3 min intervals, 10 cycles(5 cycles, micro format only)

Maximum Caustic Exposure

1.0 N NaOH at 50 °C(Contact us for exposure parameters.)

PH Range

1-14

 

Commercial Mfg – Bioprocess Filtration Workflow

 

Cell Harvesting

The separation and recovery of cells from fermentation.

01

Lysate Clarification

The separation and recovery of target molecules from cell debris (membrane fragments) and intact cells following cell lysis.

02

Product Fractionation

Protein separation based on molecule size.

03

Concentration

The concentration of retained proteins by removing unwanted solvents and small molecules.

04

Diafiltration

The exchange of buffer solution to final buffer formulation for additional processing.

05

 

Tangential Flow Filtration Cassette

 

Applications of Commercial Mfg—Lab Use TFF System

Concentration And Desalting: Proteins, peptides, nucleic acids (DNA, RNA)


Separation And Purification: Enzymes, antibodies, recombinant proteins, viruses, vaccines, etc.


Buffer Exchange: Solvent removal, dialysis, etc.


Clarification: Cell lysates, tissue homogenates, etc.


Depyrogenation: Such as water, buffer, culture medium, etc.


Sample pretreatment that requires column chromatography.


Cell collection Virus concentration, such as oncolytic measles virus


Clinical: Hemodialysis and hemoglobin purification

 

Choosing the Right Commercial Mfg—Lab Use TFF System

Selecting the ideal TFF system is not a one-size-fits-all approach. Factors related to process requirements, automation capabilities, ease-of-use, budget and compliance all have an impact on the selection process. TFF system requirements for research students in an academic laboratory will strongly vary from the needs of operators producing therapeutics. So, understanding what the goals and user requirements are becomes key to the selection process.

 

Beyond any present research or formulation development, consideration is also needed for future planning. In many cases scalability, for example, is a critical factor for selecting a TFF system because it will directly impact production capabilities. An inability to increase production volume within allotted deadlines while maintaining quality standards creates bottlenecks that put projects and even pharmaceutical companies at risk. Therefore, choosing the right TFF system has to account for present and future bioprocessing needs.

 

 

Certificate

 

productcate-1-1

 

Delivery Information

Shipping Methods

We offer a variety of shipping options, including sea freight, air freight, railway transportation, and international express delivery, to meet the diverse needs of our customers.

Estimated Delivery Time

We will provide you with the estimated delivery time for your order, which will be clearly stated in the formal order to ensure your rights are protected, allowing you to arrange for the receipt of your goods in a timely manner.

Order Tracking

We provide order tracking services, allowing you to stay informed about the current status and expected arrival time of your order. Detailed inspection information and shipping manifests, including photos and videos, are provided to ensure the security of your transactions.

 

 

FAQ

 

Q: What is the purpose of tangential flow filtration?

A: Tangential flow filtration (TFF) is a rapid and efficient method for separation and purification of biomolecules. It can be applied to a wide range of biological fields such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology.

Q: What are the different types of tangential flow filtration?

A: The Tangential Flow Filtration method can be applied using various types of tff filtration membrane modules, including flat plate (also known as cassette or capsule), hollow fiber, and spiral wound modules.

Q: What is a TFF membrane?

A: Tangential Flow Filtration (TFF) is a method of separating, purifying, and concentrating therapeutic biomolecules. This method is applied by the feed solution flowing parallel (or tangentially) across the membrane surface instead of directly through it.

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