Primary Recovery

Your Professional Primary Recovery Supplier

Hangzhou Guidling Technology CO.,LTD is an innovative manufacturer focusing on providing solutions (clarification, separation and concentration, etc.) in the downstream field of biopharmaceutical. Guidling Technology has successfully developed centrifugal filter devices, ultrafiltration & microfiltration cassettes and TFF device and system, depth filter modules, virus clearance filter, etc.

Why Choose Us

ISO-Certified Quality Management

We are certified under ISO 9001:2015 / GB/T 19001-2016 by internationally recognized bodies (IAF/IAS), ensuring strict process control and consistently reliable product quality throughout manufacturing.

Scalable Filtration Solutions

We provide integrated clarification, filtration, and concentration systems designed to support seamless scale-up from laboratory to full-scale industrial production.

Proven Biopharma Applications

Our filtration technologies are widely used in antibody, vaccine, and biologics manufacturing, enabling stable and efficient clarification, separation, and virus removal processes.

Parameter

Cut off	0.11㎡filter area	0.5㎡filter area	1.3㎡filter area	2.5㎡filter area
1kd	G01100001K	G05000001K	G13000001K	G25000001K
5kd	G01100005K	G05000005K	G13000005K	G25000005K
8kd	G01100008K	G05000008K	G13000008K	G25000001K
10kd	G01100010K	G05000010K	G13000010K	G25000010K
30kd	G01100030K	G05000030K	G13000030K	G25000030K
50kd	G01100050K	G05000050K	G13000050K	G25000050K
100kd	G01100100K	G05000100K	G13000100K	G25000100K
300kd	G01100300K	G05000300K	G13000300K	G25000300K
500kd	G01100500K	G05000500K	G13000500K	G25000500K

Advantages of Primary Recovery in Bioprocessing

Downstream Protection

Captures insoluble impurities and helps prevent fouling or clogging in chromatography columns and membrane systems.

Product Recovery

Chromatography and membrane-based technologies, including acoustic wave separation, can achieve product recovery above 95% with minimal losses.

Impurity Clearance

Reduces residual DNA and host cell proteins early in the process, meeting typical downstream purity requirements (e.g., <500 ppb DNA).

Scalable Operation

Modular systems support scale-up from early development to pilot and commercial manufacturing.

Integrated Primary Recovery and Bioprocess Development

Compare these unit operations for suitability within the process

Determine the most appropriate equipment for separations and specify the right operating conditions

Learn to use Ultra Scale Down tool for prediction of large scale separation performance

Understand the interaction among fermentation, recovery and purification and learn the integrated solutions for bioprocess development

Certificate

productcate-1-1

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FAQ

Q: What is clarification used for?

A: Clarification is an essential step in a water or wastewater treatment process to remove suspended solids through gravity settling, providing a clarified liquid effluent.

Q: What is the difference between clarification and filtration?

A: Filtration is a broad mechanical or physical separation process that removes solid particles from a fluid (liquid or gas) using a porous medium. Clarification is a specialized, highly specific type of filtration used when the solid content is extremely low (usually less than 1.0% of the total volume).

Q: What is clarification in bioprocessing?

A: In biopharmaceutical processes, clarification refers to the cell culture harvest step during the upstream where the crude cell culture broth or fermentation broth is separated to remove insoluble solids, cells, cell debris, and other particulate matter from the desired product solution.

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