Multiple Stages

Your Professional Multiple Stages Supplier

Hangzhou Guidling Technology CO.,LTD is an innovative manufacturer focusing on providing solutions (clarification, separation and concentration, etc.) in the downstream field of biopharmaceutical. Guidling Technology has successfully developed centrifugal filter devices, ultrafiltration & microfiltration cassettes and TFF device and system, depth filter modules, virus clearance filter, etc.

Why Choose Us

ISO-Certified Quality Management

We are certified under ISO 9001:2015 / GB/T 19001-2016 by internationally recognized bodies (IAF/IAS), ensuring strict process control and consistently reliable product quality throughout manufacturing.

Scalable Filtration Solutions

We provide integrated clarification, filtration, and concentration systems designed to support seamless scale-up from laboratory to full-scale industrial production.

Proven Biopharma Applications

Our filtration technologies are widely used in antibody, vaccine, and biologics manufacturing, enabling stable and efficient clarification, separation, and virus removal processes.

Parameter

Membrane	Polyethersulfone
Gaskets	Pvdf ort Thermoplastic elastomer
Spacer	Polipropylene
Preservative	1.6% Phosphoric Acid,1.1% Acetic Acid,20% glycerin and water
Sealing compound	Silicone white

Features of Multiple Stages Filtration

Designed for tangential flow filtration (TFF) systems

Suitable for both upstream and downstream bioprocess applications

High flux performance for efficient processing

Precise molecular weight cut-off for reliable separation

Maintains product integrity throughout filtration

Improves process consistency and operational stability

Ideal for concentration, diafiltration, and purification processes

Multiple Stages Filtration Process

Pre-filter: The workload shield

Catches the bulk of larger particles so the main filter does not clog prematurely. Low cost and quick to change — keep spares on site and swap as soon as resistance rises.

Main filter: High-efficiency capture

High-efficiency element (often HEPA H13/H14 where fine or hazardous dusts are present) for respirable fractions. It relies on an intact seal — a damaged gasket can cause bypass even when the filter media is sound.

Post-filter or polishing stage

Captures any remaining fine particulate and protects the motor or downstream ducting. Optional odour or chemical stages (such as activated carbon) are task-dependent and add resistance.

Certificate

productcate-1-1

Flexible Global Shipping Solutions

We support multiple shipping methods including sea freight, air freight, rail transportation, and express delivery to meet different delivery timelines and project requirements. Professional packaging and export handling ensure safe and efficient transportation for international orders.

FAQ

Q: What is tangential flow filtration (TFF)?

A: Tangential flow filtration (TFF) is a method in which the feed flows along the membrane surface, generating tangential shear to reduce membrane fouling and clogging. TFF is commonly applied as ultrafiltration (1–1000 kDa) or microfiltration (0.1–0.65 µm).

Q: How to choose the appropriate ultrafiltration membranes?

A: For most ultrafiltration and dialysis applications, both PES and RC membranes are suitable choices.
PES membranes can meet a wide range of application needs for most protein and small-molecule products, such as antibodies, APIs, and vaccines.

Q: Can TFF cassettes be reused?

A: Yes. TFF cassettes can be reused by selecting appropriate cleaning methods. However, due to changes such as declining membrane flux and increased permeation, the cassettes should be replaced periodically as needed.

(0/10)