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Tangential Flow Filtration System

Your Professional Tangential Flow Filtration System Supplier

Hangzhou Guidling Technology CO.,LTD is an innovative manufacturer focusing on providing solutions (clarification, separation and concentration, etc.) in the downstream field of biopharmaceutical. Guidling Technology has successfully developed centrifugal filter devices, ultrafiltration & microfiltration cassettes and TFF device and system, depth filter modules, virus clearance filter, etc.

Why Choose Us

ISO-Certified Quality Management

We are certified under ISO 9001:2015 / GB/T 19001-2016 by internationally recognized bodies (IAF/IAS), ensuring strict process control and consistently reliable product quality throughout manufacturing.

Scalable Filtration Solutions

We provide integrated clarification, filtration, and concentration systems designed to support seamless scale-up from laboratory to full-scale industrial production.

Proven Biopharma Applications

Our filtration technologies are widely used in antibody, vaccine, and biologics manufacturing, enabling stable and efficient clarification, separation, and virus removal processes.

Parameter

Reservoir O-ring	EP Rubber
Magnetic Stir Bar	PTFE coated
Gauge Wetted Parts	316L stainless steel
Gauge Mounting Block	Polypropylene
Luer Fittings	Polypropylene and stainless steel
Tubing	C-flex﹡
Four-way Valves	Polycarbonate body, polyethylene core
Drip Tray	Urethane

Benefits of Tangential Flow Filtration System

Enhanced Product Recovery

By avoiding filter clogging and reducing protein adsorption, these methods ensure higher yields of biologically active products.
Scalability

Both technologies are easily scalable from laboratory to production scale without significant changes in process parameters, ensuring consistent product quality.
Reduced Processing Times

Continuous flow operation allows for faster processing compared to batch filtration methods.
Cost Efficiency

Minimized product loss and lower operational costs due to prolonged filter life and reduced downtime.

Application of Tangential Flow Filtration System

TFF used in research of viruses.
TFF setup using a Masterflex peristaltic pump system produced results with a higher concentration of viruses captured by the tangential flow filter than that from a system with less filtration control.
Case study: Study of the viruses that inhabit the intestines of a cow.He ran samples from a reservoir through the peristaltic pump and the pressure gauge into the tangential flow filter. He used two filters in separate processes: a 0.2 µm filter to remove bacteria and a <100 kD filter to concentrate the viruses.

TFF has been used by vintners and oenologists — winemakers and wine scientists —to:
Produce cleaner wines
Filter out cellular debris
Cut costs on bottling final filters
TFF has also found its way into food and pharmaceutical processing, where continuous purification speeds the innovation process.

Certificate

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FAQ

Q: Is tangential flow filtration the same as ultrafiltration?

A: Tangential Flow Filtration (TFF) is the prevailing technique used in ultrafiltration and is commonly employed in various biological fields, including molecular biology, biochemistry, immunology, protein chemistry, and microbiology.

Q: How to perform tangential flow filtration?

A: The membrane is installed (or a disposable TFF capsule selected), and the TFF System is initialized (typically flushed with water and tested for water filtrate flow rate and integrity). Sample is added, a crossflow is established, feed and retentate pressures are set, then filtrate is collected.

Q: What is tangential flow filtration?

A: What is tangential flow filtration? | tff filtration vs ...Tangential Flow Filtration (TFF)—also known as cross-flow filtration—is a separation technique where a fluid flows parallel to a filter membrane rather than pushing directly through it. This continuous flow sweeps the membrane surface, preventing clogging (fouling) and allowing for highly efficient processing, concentration, and purification of biomolecules.

As one of the leading tangential flow filtration system manufacturers and suppliers in China, we also support customized service. We warmly welcome you to wholesale high quality tangential flow filtration system in stock here from our factory. For quotation, contact us now.

cross flow filtration system

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