Technical features of tangential flow filtration devices

Tangential flow ultrafiltration (TFL) systems are specialized analytical instruments that operate by directing the liquid flow perpendicular to the filtration direction. This flushing of the membrane surface prevents gel formation, thus maintaining a stable ultrafiltration rate. These systems are widely used in biopharmaceuticals, antibiotic detection, preparation of biopharmaceutical nanoparticles and medical nanocarriers, and ultrapure water production. They are suitable for large-scale liquid filtration in R&D, pilot-scale production, and industrial applications. TFL systems are multifunctional, capable of concentration, purification, dialysis, and buffer replacement. Their key features include optimized tubing design, automated control, and linearly scalable processing capabilities.

TFL systems employ a cross-flow filtration method, with the liquid flow perpendicular to the membrane surface. This flushing prevents gel formation and maintains a stable ultrafiltration rate. The system can be configured with different membrane types (e.g., hollow fiber or plate membrane packs) and membrane areas (up to 3700 cm²). An automated control module enables constant flow, constant pressure operation, and data recording. Some systems are equipped with expansion modules such as feed pumps and pH/UV detection, and the process temperature range is typically 4°C-50°C.