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Downstream Process System Integration:
Custom engineering of turn-key bioprocess purification skids.
Application-Based Configuration:
Tailored fluid pathways designed around specific target molecule characteristics.
Seamless Scalability:
Linear scale-up capabilities ensuring consistent process principles from benchtop to production.
Batch-to-Batch Repeatability:
Advanced flow and pressure control to guarantee stable and reproducible product quality.
Global Compliance & Export Experience:
Proven track record in delivering regulatory-compliant systems to international biopharma markets.
Overview
Jiuling's Protein Purification Systems are engineered to separate, concentrate, and purify high-value biomolecules, including monoclonal antibodies (mAbs), recombinant proteins, enzymes, and vaccine components. Positioned at the critical stages of downstream processing, our systems are optimized to maximize product recovery while maintaining strict operational stability.
|
Parameter |
Specification / Range |
|
Processing Volume |
1 L – 2,000 L |
|
Molecular Weight Cut-Off (MWCO) |
1 kDa – 1,000 kDa |
|
Operation Mode |
Tangential Flow Filtration (TFF) / Recirculation |
|
System Structure |
Ergonomic Skid-Mounted or Modular Open-Frame Design |
|
Control Level |
Manual / Semi-Automatic / Fully Automated (PLC/SCADA, 21 CFR Part 11 ready) |
|
Membrane Compatibility |
Cassettes / Hollow Fiber modules (Flexible holder options) |
|
Wetted Materials |
USP Class VI compliant (SS316L, EPDM, PTFE, Silicone) |
|
Surface Finish |
Internal Ra < 0.4 μm, Electropolished (Standard for biopharma lines) |
Validated Process Performance: Maintains constant transmembrane pressure and cross-flow velocity for predictable, reproducible production cycles.
True Linear Scalability: Identical fluid dynamics pathways allow seamless scale-up from R&D to manufacturing scale without altering the core workflow.
High-Tier Bioprocess Compatibility: All contact materials are fully traceable, non-toxic, and resistant to standard biopharma buffers, CIP chemicals, and SIP sterilization.
Optimized Product Recovery: Dead-leg minimizing designs and low system hold-up volumes drastically reduce protein loss during harvesting.
Highly Flexible & Modular Customization: Systems can be fully tailored according to processing volumes, target molecular traits, single-use vs. reusable preferences, and plant DCS integration needs.
System Application Stages
Clarification & Pre-Filtration
Used for the removal of cells, cell debris, and insoluble materials immediately following fermentation or cell culture harvesting.
High-dirt-holding pre-filtration to protect downstream purification units.
Stabilization of feed quality prior to chromatography or ultrafiltration.
Concentration & Diafiltration (UF/DF)
Ultrafiltration-based separation utilized for protein concentration and continuous buffer exchange.
Precise molecular weight-based separation using tangential flow filtration (TFF).
Efficient buffer removal or replacement via automated/manual diafiltration.
Controlled, pressure-driven operation to prevent membrane fouling and protein gel-layer formation.
Final Purification Support
Deployed as a polishing step prior to final formulation and sterile filling.
Removal of trace impurities, aggregates, and endotoxins.
Optimization of final product purity and conditioning for long-term storage.
System Configuration Options
Tangential flow filtration (TFF) systems
Ultrafiltration / diafiltration modules
Single-use or reusable flow path options
Lab, pilot, and production-scale systems
Integrated flow, pressure, and process control systems
To meet the stringent requirements of international regulatory audits, all Jiuling systems are built under rigorous quality management protocols.
Material Traceability
Complete material tracking with Mill Test Reports and USP Class VI compliance certificates for all wetted parts.
Standardized Manufacturing
Produced in compliance with ASME BPE and cGMP guidelines.
Rigorous Testing
Multi-stage quality audits, including extensive pressure-hold testing and software loop-checks before dispatch.
Validation Support
Comprehensive DQ/IQ/OQ documentation packages provided to accelerate your site validation.
We provide system customization based on downstream process requirements and integration conditions.
System scale and capacity adjustment
Flow rate and pressure configuration
Membrane type and compatibility options
Single-use or reusable system selection
Process-specific engineering optimization
Reinforced Sea/Air Freight Packaging
Heavy-duty, IPPC-certified wooden crates with anti-vibration cushioning and vacuum barrier sealing.
Modular Disassembly
Strategic component partitioning to facilitate easier rigging and setup in cleanroom environments.
Clear Documentation
Detailed system assembly guides, P&ID drawings, electrical schematics, and full commercial export paperwork (Invoice, Packing List, Certificate of Origin).
Flexible Incoterms
Supporting EXW, FOB, CIF, and DDU/DDP terms based on project procurement needs.
Inquiry & Technical Support
Jiuling provides protein purification systems designed for real downstream processing requirements in biopharmaceutical production.
We support:
●Laboratory and R&D systems
●Pilot-scale process development systems
●Industrial production systems
●Customized engineering solutions
Request system selection support or quotation based on your process conditions.
Our engineering team will review your application and provide a suitable system proposal.
As one of the leading protein purification systems manufacturers and suppliers in China, we also support customized service. We warmly welcome you to wholesale high quality protein purification systems in stock here from our factory. For quotation, contact us now.
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