Laboratory Scale Tangential Flow Filtration System
Jiuling Filtration is a premier, quality-driven manufacturer and exporter of Tangential Flow Filtration (TFF) systems dedicated to biopharmaceutical and biotechnology applications. We specialize in engineering practical, highly reproducible, and scalable laboratory filtration platforms. Our systems are widely adopted globally for critical downstream workflows, including protein purification, viral vector processing, and advanced buffer exchange.
- Product Introduction
Company Overview
Jiuling Filtration is a premier, quality-driven manufacturer and exporter of Tangential Flow Filtration (TFF) systems dedicated to biopharmaceutical and biotechnology applications. We specialize in engineering practical, highly reproducible, and scalable laboratory filtration platforms. Our systems are widely adopted globally for critical downstream workflows, including protein purification, viral vector processing, and advanced buffer exchange.
Product Overview
The Jiuling Laboratory Scale Tangential Flow Filtration (TFF) System is a high-performance cross-flow platform engineered for early-stage process development, optimization, and scale-up studies.
Unlike conventional dead-end filtration, our TFF system continuously recirculates the feed hydrodynamically across the membrane surface. This specialized sweeping action drastically minimizes concentration polarization and membrane fouling, ensuring stable, long-duration operations for high-value bioprocesses.
Technical Specifications
|
Parameter |
Specification |
|
Working Volume |
50 mL – 5 L |
|
Process Modes |
Concentration / Diafiltration / Buffer Exchange |
|
Pump Type |
Peristaltic pump (standard), diaphragm pump (optional) |
|
Flow Control |
Manual or adjustable digital control |
|
Operating Pressure |
0 – 4 bar (depends on configuration) |
|
Membrane Types |
Flat sheet cassette / hollow fiber |
|
MWCO Range |
1 kDa – 0.2 µm |
|
Wetted Materials |
PP / PVDF / 316L stainless steel (optional) |
|
Tubing Material |
Silicone / PharMed / PTFE |
|
Sterilization |
Compatible with CIP/SIP or single-use setup |
|
Monitoring |
Optional pressure and flow data logging |
Key Features
Stable Cross-Flow Operation
Cross-flow design keeps particles moving along the membrane surface, reducing buildup and maintaining more stable flux during operation.
Designed for Process Development
The system is intended for method development and parameter optimization. Flow rate, pressure, and membrane type can be adjusted to establish reproducible process conditions.
Low Sample Requirement
Suitable for early-stage development where material is limited. The system supports small working volumes without compromising process control.
Scale-Up Relevance
Operating conditions can be adjusted to simulate pilot-scale hydrodynamics, helping improve consistency during scale-up and process transfer.
Modular Design
Each component can be configured or replaced independently, allowing flexible adaptation to different process requirements.
Application Areas
Biologics & Therapeutics: Monoclonal antibodies (mAbs), recombinant proteins, enzymes, and plasma fractionation.
Gene & Cell Therapy: Concentration and purification of Viral Vectors (AAV, Lentivirus, Adenovirus).
Vaccine Manufacturing: Purification and concentration of viral antigens, mRNA LNPs, and bacterial capsular polysaccharides.
Advanced Biomolecules: Exosome isolation, synthetic nanoparticles, and oligonucleotide purification.
Research Institutions: Academic, clinical, and industrial bioprocess R&D laboratories.
System Configuration
The system features a highly flexible, modular architecture that allows users to switch between different filtration form factors seamlessly.
Standard Setup
Feed Reservoir: Premium USP Class VI graduated glass or 316L stainless steel vessel.
Recirculation Pump: Precision peristaltic pump with adjustable digital speed control for low-shear fluidics.
Universal Membrane Holder: Fully compatible with standard flat-sheet cassettes and hollow fiber modules.
Multi-Point Monitoring: Integrated sanitary pressure indicators at Feed, Retentate, and Permeate channels.
Flow Control: Heavy-duty, fine-adjustable retentate control valves for precise Transmembrane Pressure tuning.
Permeate Collection: Calibrated collection container with medical-grade bioprocess tubing.
Optional Advanced Configurations
Digital PAT Module: High-precision digital pressure sensors with real-time automate data output.
Data Logging Software: Automated module for live tracking and exporting of pressure, flow rate, and flux curves.
Single-Use Fluid Path: Gamma-irradiated, fully disposable single-use tubing manifolds to eliminate cross-contamination.
Fully Automated Control: Automated flow/pressure maintenance module for advanced TMP step-studies.
System Selection Guide
By Working Volume
50 mL – 250 mL: Initial feasibility studies, membrane screening, and small-volume antigen concentration.
250 mL – 2 L: Standard bioprocess development, parameter optimization (TMP mapping), and formulation design.
2 L – 5 L: Pre-pilot scale-up simulation, toxicity batch production, and process validation.
By Target Molecule
1 kDa – 10 kDa: Small peptides, oligonucleotides, and low-molecular-weight protein concentration.
10 kDa – 100 kDa: Monoclonal antibodies (mAbs), large recombinant enzymes, and albumin processing.
100 kDa – 0.2 µm: Viral vectors (AAV, Lentivirus), exosomes, mRNA LNPs, and cell harvesting/clarification.
Why Global Laboratories Partner with Jiuling
Regulatory Peace of Mind: All product-contact materials are fully compliant with USP Class VI and FDA guidelines, ensuring easy integration into regulated cGMP environments.
Universal Compatibility: Open-architecture design accepts standard cassettes and hollow fibers from major global manufacturers.
Data Integrity Ready: Optional automated logging tracks your critical process parameters (CPP), supporting modern QbD (Quality by Design) workflows.
End-to-End Application Support: We don't just export hardware. Our application engineers provide comprehensive process, membrane, and scale-up consultation.
Customization Flexibility: Custom engineered wetted paths, automated loops, and tailored sizing are available upon request to meet exact process specifications.
FAQ
Q: Is the system compatible with standard TFF cassettes?
A: Yes. It supports commonly used cassette formats depending on configuration.
Q: Can it be used for viral vector concentration?
A: Yes, with appropriate membrane selection.
Q: What is the minimum working volume?
A: As low as 50 mL depending on setup.
Q: Can it support scale-up development?
A: Yes. It is designed for process development and scale-up simulation.
Q: Is data monitoring available?
A: Optional pressure and flow data logging modules can be integrated.
Q: What industries use this system?
A: Biopharmaceutical, gene therapy, vaccine development, and research institutions.
Q: How is fouling controlled?
A: Cross-flow operation reduces membrane surface buildup.
Q: Can the system be customized?
A: Yes. Configuration can be adjusted based on process requirements.
Inquiry & Technical Support
Jiuling Filtration provides laboratory-scale TFF systems for bioprocess development and scale-up studies.
We support:
- System configuration recommendation
- Membrane selection guidance
- Process application consultation
- Technical layout support
Contact us with your process requirements to receive a tailored system proposal.
Hot Tags: laboratory scale tangential flow filtration system, China laboratory scale tangential flow filtration system manufacturers, suppliers, factory, High Flux Tangential Flow Filtration System
