High Flow Single-Use Filtration Assembly
The system integrates filter media, tubing, and connectors into a pre-assembled disposable unit. It is installed directly into the process line and does not require stainless steel housing or CIP/SIP cleaning cycles.
- Product Introduction
Product Overview
High Flow Single-Use Filtration Assembly is designed for liquid processes that require higher throughput within limited processing time.
The system integrates filter media, tubing, and connectors into a pre-assembled disposable unit. It is installed directly into the process line and does not require stainless steel housing or CIP/SIP cleaning cycles.
Technical Specifications
|
Specification |
Description |
|
Filtration Ratings |
0.1 μm / 0.2 μm / 0.45 μm / 1.0 μm |
|
Filtration Media Options |
PES / PP / PVDF / Cellulose-based depth media (optional) |
|
Flow Design |
High-flow structure with controlled pressure drop for batch processing |
|
Filter Media |
Polyethersulfone (PES), Polypropylene (PP), PVDF, Cellulose |
|
Housing Material |
Medical-grade polypropylene (PP) |
|
Tubing Material |
Silicone / Thermoplastic Elastomer (TPE) |
|
Pressure Range |
Designed for standard bioprocess operating pressure conditions |
|
Fluid Compatibility |
Aqueous solutions, buffers, and biological process fluids |
|
Sterilization |
Gamma irradiation compatible (optional supply) |
|
Standard Connections |
Tri-Clamp (TC), Hose Barb, Sterile Welding Connectors |
|
Custom Options |
Custom single-use connectors available upon request |
Key Features
Stable High-Flow Design
Flow path is optimized to reduce local resistance and maintain stable operation during batch filtration.
Pre-Assembled Disposable Format
Delivered ready to use, reducing installation steps and eliminating assembly variability.
Closed Processing Path
Minimizes exposure risk during transfer and operation.
Batch-to-Batch Consistency
Manufactured under controlled conditions to ensure consistent filtration behavior.
Application Areas
Vaccine manufacturing processes
Cell culture harvest clarification
Fermentation broth filtration
Food and beverage clarification
Cosmetic ingredient purification
Fine chemical intermediate processing
Process-Based Rating Guidance
0.1 – 0.2 μm: Sterile filtration prior to filling or final bioburden control.
0.45 μm: Intermediate clarification after upstream cell removal.
1.0 μm: Pre-filtration for high-particle loads or downstream membrane protection.
Crucial Operating Considerations
Fluid Dynamics: Effective flow rates are directly influenced by fluid viscosity, solid content, filtration area, and operating pressure.
Pressure Management: Higher solids loads accelerate pressure rise. For fermentation broths or high-viscosity feeds, a properly configured pre-filter or depth filter is highly recommended to prevent premature clogging and maintain a stable flow rate.
System Limits: Designed for controlled batch processes; not intended for long-duration, continuous industrial operation.
Quality Control
Every single-use assembly is manufactured under rigorous quality management systems to ensure batch-to-batch consistency and process safety.
Controlled Environment: Assembled and packaged within a controlled cleanroom environment to minimize particulate background.
Material Traceability: Full batch traceability system for all raw materials and components, supporting global export and regulatory audits.
Integrity Assured: Strict incoming material inspection and integrity testing for critical sterile-grade assemblies.
Validation Documentation: Complete validation guides (including bacterial retention, endotoxin levels, and extractables data) can be provided based on project requirements.
Why Choose Jiuling?
Focused Manufacturing Expertise: Dedicated solely to high-quality single-use filtration technologies.
Engineering-Driven Customization: Comprehensive OEM support with custom tubing lengths, layouts, and connector configurations.
Global Supply Chain Readiness: Experienced in international logistics with complete regulatory and export documentation.
Application Support: Our technical team assists you from initial sizing and scale-up to final process integration.
FAQ
Q: Can this assembly completely replace stainless steel filter housings?
A: Yes, it is designed to replace small-to-mid-scale stainless steel housings in batch production where reducing cleaning validation (CIP/SIP) is a priority. However, it is optimized for batch applications and is not intended for continuous, non-stop industrial filtration.
Q: What options are available regarding sterilization?
A: We offer both gamma-irradiated (ready-to-use sterile) and non-sterile formats depending on your process requirements and facilities.
Q: How do we handle high solid content or high viscosity in the feed?
A: High solids or viscosity will accelerate pressure rise. We recommend incorporating a 1.0 μm pre-filter or depth filtration media step, or scaling up the effective filtration area. Our engineers can help calculate the optimal sizing.
Q: Can the tubing and layout be customized for our existing hardware?
A: Absolutely. We support full customization of tubing lengths, materials (Silicone/TPE), and connector types (TC, quick-connects, sterile welding) to match your exact single-use platform.
Q: What validation support do you provide for biopharmaceutical clients?
A: We provide comprehensive documentation support, including material certificates of compliance (USP Class VI, FDA), lot traceability, and configuration drawings. Full validation guides are available upon request for specific projects.
Inquiry
To recommend a suitable configuration, we usually evaluate:
- Fluid type
- Flow rate requirement
- Batch volume
- Filtration stage
Please share your process conditions for technical selection support.
We support global OEM and industrial supply requirements for single-use filtration systems.
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